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高エネルギーボールミル Emax

アプリケーションレポート (5)

  • 高エネルギーボールミルEmaxで、医薬品研究における粉砕時の発熱低減と粉砕時間短縮

    難溶解性、不溶解性活性薬剤の開発は、製薬産業にとって、大きな挑戦です。経口投与による薬剤のバイオアベイラビリティー(投与された薬物がどれだけ全身循環血中に到達し、作用するかの指標)は、胃腸管(消化管)部位における溶解度に依存します。 薬剤の溶解性とバイオアベイラビリティーとは密接な関係にあり、薬剤の微粉化が、その鍵となります。難溶解性薬剤の粒子サイズをミクロンサイズから、ナノサイズにまで微粉化する事により、粒子の表面積は増加し、これにより薬剤の溶解性は一層高まります。粉砕された粒子は、例えば錠剤、カプセル錠のような、異なる剤形として適宜に使用されます。 レッチェの新製品、高エネルギーボールミルEmaxは、これまで多くの時間がかかっていたサブミクロンからナノメートル領域までの粉砕時間を大幅に削減する事ができる画期的なボールミルです。最大2,000rpmの回転数と独自の駆動方式により、既存の、どのボールミルと比べても、より速く、より効果的に粉砕を行う事が可能になりました。
  • Emax - faster, finer, cooler

    The biggest challenge when developing a high energy ball mill is controlling the temperature. The very high energy produced by ball milling leads to an extreme heat increase inside the grinding jars. RETSCH solved this problem by creating an innovative integrated water-cooling system. Grinding breaks for cooling, which are unavoidable in conventional ball mills even after only 30 minutes grinding at moderate speed, are usually not necessary when using the High Energy Ball Mill Emax.
  • White Paper: Ultrafine Grinding with Laboratory Ball Mills

    How are nano particles produced? The “Bottom-Up” method synthesizes particles from atoms or molecules. The “Top-Down” method involves reducing the size of larger particles to nanoscale, for example with laboratory mills. Due to their significantly enlarged surface in relation to the volume, small particles are drawn to each other by their electrostatic charges. Nano particles are produced by colloidal grinding which involves dispersion of the particles in liquid to neutralize the surface charges. Both water and alcohol can be used as dispersion medium, depending on the sample material. Factors such as energy input and size reduction principle make ball mills the best choice for the production of nanoparticles.
  • Emax - The Revolution in Ultrafine Grinding

    The Emax is an entirely new type of ball mill which was specifically designed by RETSCH for high energy milling. The impressive speed of 2,000 min-1, so far unrivaled in a ball mill, in combination with the special grinding jar design generates a vast amount of size reduction energy. The unique combination of impact, friction and circulating grinding jar movement results in ultrafine particle sizes in the shortest amount of time. Thanks to the new liquid cooling system, excess thermal energy is quickly discharged preventing both sample and mill from overheating, even after long grinding times.
  • Mechanical Alloying with High Energy Ball Mill Emax

    Alloys such as amalgam in dental medicine or stainless steel are universally known and used. The traditional way to produce alloys is to fuse the components at very high temperatures. If only small quantities are required or if the alloys cannot be fused by melting mechanical alloying is an alternative. For this application ball mills are ideally suited. They provide a high energy input due to the impact and friction effects which occur during grinding.

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